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Naturally-occurring serotype 3 Streptococcus pneumoniae strains that lack functional pneumolysin and autolysin have attenuated virulence but induce localized protective immune responses.
Ηαnnah E Wong, Panagiotis Tourlomousis, Gavin K Paterson, Steve Webster, Clare E Bryant
Apr 09, 2023
Streptococcus pneumoniae is an important cause of fatal pneumonia in humans. These bacteria express virulence factors, such as the toxins pneumolysin and autolysin, that drive host inflammatory responses. In this study we...
Animals Horses Mice Streptococcus pneumoniae N-Acetylmuramoyl-L-alanine Amidase Tumor Necrosis Factor-alpha Bacterial Proteins Streptolysins Virulence Immunity Serogroup
Published by: PLOS ONE
Optimizing Water Quality Sampling Through Application Of Real Time Ionic Concentration Regression Models
The Water Resources Management Division of the Department of Environment and Conservation performs routine water sampling to measure the physical and chemical parameters of select water bodies in Newfoundland and Labrador. Ionic...
Cognitive Behavioural Therapy for Sexual Offenders With Autism Spectrum Disorders
The vast majority of individuals with autism do not commit sexual offenses. While there has been some suggestion of a tendency towards anti-social or offending behaviors, a propensity for breaking the law by those with a...
Published by: IGI Global
Solution NMR of Battery Electrolytes
NMR spectroscopy is a powerful tool that is commonly used to assess the degradation of lithium-ion battery electrolyte solutions. However, dissolution of paramagnetic Ni2+ and Mn2+ ions from cathode...
People Who Need Data People
UW-Madison has a thriving community of support around research data management and sharing, computational skills, and research reproducibility which are all building blocks for supporting campus data science needs. Support is...
Library and Information Science Library Science Data Management Computer Science and Information Technology Education
Published by: IGI Global
Label-free cell segmentation of diverse lymphoid tissues in 2D and 3D.
John W Wills, Jack Robertson, Pani Tourlomousis, Clare M C Gillis, Claire M Barnes, Michelle Miniter, Rachel E Hewitt, Clare E Bryant, Huw D Summers, Jonathan J Powell, Paul Rees
Apr 17, 2023
Unlocking and quantifying fundamental biological processes through tissue microscopy requires accurate, in situ segmentation of all cells imaged. Currently, achieving this is complex and requires exogenous fluorescent...
confocal microscopy immunofluorescence Tissue Quantitative Cell segmentation 3D digital pathology Label Free 2D single-cell
Published by: Cell reports methods
Provision of palliative and end-of-life care in UK care homes during the COVID-19 pandemic
Andy Bradshaw, Sophia Ostler, Claire Goodman, Izabele Batkovskyte, Clare Ellis-Smith, India Tunnard, Anna E Bone, Stephen Barclay, Martin Vernon, Irene J Higginson, Catherine J Evans, Katherine E Sleeman
Apr 17, 2023
Introduction
Little consideration has been given to how the provision of palliative and end-of-life care in care homes was affected by COVID-19. The aims of this study were to: (i) investigate the response of UK care...
Policy Palliative Care care homes end-of-life care mixed methods observational covid-19 Humans Terminal Care Cross-Sectional Studies Pandemics United Kingdom covid-19
Published by: Frontiers in public health
Circulating proteins to predict COVID-19 severity
Abstract Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4701 circulating human protein abundances...
Chen-Yang Su, Sirui Zhou, Edgar Gonzalez-Kozlova, Guillaume Butler-Laporte, Elsa Brunet-Ratnasingham, Tomoko Nakanishi, Wonseok Jeon, David R Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye, Tala Abdullah, Noor Almamlouk, Yara Moussa, Chantal DeLuca, Naomi Duggan, Erwin Schurr, Nathalie Brassard, Madeleine Durand, Diane Marie Del Valle, Ryan Thompson, Mario A Cedillo, Eric Schadt, Kai Nie, Nicole W Simons, Konstantinos Mouskas, Nicolas Zaki, Manishkumar Patel, Hui Xie, Jocelyn Harris, Robert Marvin, Esther Cheng, Kevin Tuballes, Kimberly Argueta, Ieisha Scott, Celia MT Greenwood, Clare Paterson, Michael A Hinterberg, Claudia Langenberg, Vincenzo Forgetta, Joelle Pineau, Vincent Mooser, Thomas Marron, Noam D Beckmann, Seunghee Kim-schulze, Alexander W Charney, Sacha Gnjatic, Daniel E Kaufmann, Miriam Merad, J Brent Richards
Apr 17, 2023
Assessment of association between lower ureteric excision technique and oncological outcomes for upper urinary tract urothelial carcinoma
James Peter Blackmur, Etienne Chew, Matthew Trail, Katie Brodie, Nicola Santoni, Flora Rodger, David Hamilton, Fortis Gaba, Sophie Randall, Sarika Nalagatla, Brian Little, Khalid Janjua, Clare Sweeney, Andrew Martindale, Khaver Qureshi, Antony Riddick, Kevin O'Connor, S Alan McNeill, Simon Phipps, Mark L Cutress, Edward AA Mains, Ian Dunn, Sarah Reid, Grant D Stewart, Gavin Lamb, Muhammad Zeeshan Aslam, Steve Leung, Ross Clark, Ian Wilson, Grenville Oades, Alexander Chapman, Alexander Laird
Apr 08, 2023
A practical perspective on the potential of rechargeable Mg batteries
J Alberto Blázquez, Rudi R Maça, Olatz Leonet, Eneko Azaceta, Ayan Mukherjee, Zhirong Zhao-Karger, Zhenyou Li, Aleksey Kovalevsky, Ana Fernández-Barquín, Aroa R Mainar, Piotr Jankowski, Laurin Rademacher, Sunita Dey, Siân E Dutton, Clare P Grey, Janina Drews, Joachim Häcker, Timo Danner, Arnulf Latz, Dane Sotta, M Rosa Palacin, Jean-Frédéric Martin, Juan Maria García Lastra, Maximilian Fichtner, Sumana Kundu, Alexander Kraytsberg, Yair Ein-Eli, Malachi Noked, Doron Aurbach
Apr 14, 2023